SINCE The second world war, medical science has progressed into a stage where competitive medications are available to treat the same ailment in numerous people. This isn’t just about brands (which is a trade issue) but generic drugs (which is a scientific issue). With this report, we shall consider the various factors that decide picking a a selected drug.
Safety: The subsequent sub-criteria must be considered under the criterion of safety:
* Acute therapeutic index: In the event the patient’s condition is acute, how effective is often a particular drug even if they have certain side-effects provided that the acuteness with the condition is lowered? Example: narcotic pain-killers are incredible in healing pain but have the potential side-effect of addiction.
* Long-term safety: medicine might be safe in short-term treatment, but wait, how safe it can be in long-term treatment? Example: antibiotics are acceptable in short-term treatment, but tend to have undesirable effects in case of prolonged use.
* Drug-drug interaction risk: Prescription medication is chemicals, and many chemicals react to make a different chemical, which has an effect that could harm the patient or aggravate his/her condition. Example: A tricyclic anti-depressant and alcohol interact to generate a new condition that warrants separate treatment.
Drug-drug interaction risk is of 2 types:
· Pharmacokinetic: In this type of drug-drug interaction, two drugs, independent of the other person, have certain effects one or more body processes (e.g., metabolism) that affects the performance with the other. Example: Darvocet-N (propoxyphene and acetaminophen) inhibits the action of a liver enzyme that Lexapro (escitalopram) is determined by for its metabolism. This causes a rise in the side-effects of Lexapro.
· Pharmacodynamic: Here, two or more drugs actually generate the same relation to the same organ, thus increasing the total, added effect. Example: Lexapro has certain side-effects like drowsiness and fatigue. Darvocet-N also acts similarly on the brain. Thus, the side-effects of the medicines are more intense.
Tolerability: A medication might be effective and not tolerable by all patients. Example: Allergies to particular drugs in most people. Short-term and long-term tolerability must be taken into account. Efficacy: A medication is not equally great at all patients. By way of example, some patients with depression or panic attacks experience relief from escitalopram, but there are many that don’t, who therefore must be prescribed another anti-depressant. The rate of start of therapeutic action is a vital factor to be regarded too.
Cost: Cost doesn’t imply the price of purchase of a certain medicine alone. It will also cover the price of treating a complication that could arise while using another drug. Example: Inside a individual that insists on taking alcohol and yet must be treated for depression is normally administered an SSRI drug because they drugs don’t potentiate the results of alcohol, whereas another gang of anti-depressants (like tricyclics) can cause a fresh overuse injury in such patients, which would require a various and expensive treatment. Therefore, it’s preferable to prescribe the more costly escitalopram as opposed to a cheaper tricyclic in these patients.
Simplicity of treatment: The simplest mode of administration is preferred. If there is an option between a shot and oral administration, rogues is preferred when the efficacy of the modes is the identical. Or, local application is chosen over the oral route where possible; e.g., antibiotic treating eye infections. Dosage and frequency of administration too are an important factor to choose simplicity of treatment.
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