SINCE Wwii, medical science has progressed into a stage where competitive medications are for sale to treat exactly the same ailment in various people. This is not just about brands (which is a trade issue) but generic drugs (which is a scientific issue). With this report, we shall glance at the various factors that decide picking a a selected drug.
Safety: The subsequent sub-criteria must be considered under the criterion of safety:
* Acute therapeutic index: If your patient’s condition is acute, how effective is often a particular drug even when it’s certain side-effects provided that the acuteness from the condition is lowered? Example: narcotic pain-killers work well in healing pain but feature the potential side-effect of addiction.
* Long-term safety: drug may be safe in short-term treatment, but wait, how safe it is in long-term treatment? Example: antibiotics are acceptable in short-term treatment, but sometimes have undesirable effects in the event of prolonged use.
* Drug-drug interaction risk: Medicine is chemicals, and a lot of chemicals react to develop a different chemical, which has an effect that could harm the individual or aggravate his/her condition. Example: A tricyclic anti-depressant and alcohol interact to generate a new condition that warrants separate treatment.
Drug-drug interaction risk is of two sorts:
· Pharmacokinetic: In this type of drug-drug interaction, two drugs, separate from the other, have certain effects on one or maybe more body processes (e.g., metabolism) that affects the performance from the other. Example: Darvocet-N (propoxyphene and acetaminophen) inhibits the action of a liver enzyme that Lexapro (escitalopram) is dependent upon for the metabolism. This causes a boost in the side-effects of Lexapro.
· Pharmacodynamic: Here, a couple of drugs actually make the same effect on exactly the same organ, thus helping the total, added effect. Example: Lexapro has certain side-effects for example drowsiness and fatigue. Darvocet-N also acts similarly about the brain. Thus, the side-effects of the drugs are more serious.
Tolerability: A medication may be effective and not tolerable by all patients. Example: Allergies to a particular drugs in most people. Short-term and long-term tolerability have to be looked at. Efficacy: A medication just isn’t equally effective in all patients. As an example, some patients with depression or panic disorders experience reduced escitalopram, but there are lots of that do not, who therefore have to be prescribed an alternative anti-depressant. The rate of start of therapeutic action is a crucial step to be regarded as too.
Cost: Cost does not always mean the price of purchase of a specific medicine alone. It ought to also cover the price of treating a complication that could arise from using an alternative drug. Example: In a person who insists on taking alcohol but should be treated for depression is usually administered an SSRI drug because they drugs don’t potentiate the results of alcohol, whereas another gang of anti-depressants (for example tricyclics) can cause a brand new symptom in such patients, which will demand a different and expensive treatment. Therefore, it’s preferable to prescribe the more expensive escitalopram as opposed to a cheaper tricyclic in such patients.
Simplicity of treatment: The simplest mode of administration is preferred. If there is a selection between an injection and oral administration, the second is preferred in the event the efficacy of the modes is comparable. Or, local application is chosen over the oral route where possible; e.g., antibiotic treating eye infections. Dosage and frequency of administration too are a key point to decide simplicity of treatment.
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