Selective androgen receptor modulators (SARMs) differentially bind to androgen receptors according to each SARM’s chemical structure. Therefore, SARMs cause anabolic cellular activity while avoiding most of the unwanted side effects of available today given. SARMs have been studied from the treating cancer of the breast and cachexia and have recently been used as performance-enhancing agents. Here, we evaluate and summarize the current literature on SARMs.
Aim
To give the background, mechanisms, current and potential clinical applications, as well as risks and great things about SARMs.
Methods
A literature review was performed in MEDLINE while using the terms selective androgen receptor modulator, hypogonadism, cachexia, cancers of the breast, benign prostatic hyperplasia, libido, and lean body mass. Both preliminary research and studies were included.
Main Outcome Measure
To perform overview of peer-reviewed literature.
Results
Nevertheless, there are still no U.S. Drug and food Agency-approved indications for SARMs, investigators are checking out the potential purposes of these compounds. Basic research has focused on the pharmacokinetics and pharmacodynamics of such agents, demonstrating good availability using a paucity of drug interactions. Early clinical studies have demonstrated potential uses of SARMs in the management of cancer-related cachexia, benign prostatic hyperplasia (BPH), hypogonadism, and cancer of the breast, with good success.
Conclusion
SARMs have a lot of possible clinical applications, with promise to the safe use in the treating cachexia, BPH, hypogonadism, cancers of the breast, and cancer of prostate.
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