SINCE World War II, medical science has progressed to some stage where competitive medications are for sale to treat the same ailment in different people. This is simply not just about brands (which is a trade issue) but generic drugs (which is a scientific issue). With this report, we shall consider the various factors that decide the selection of a specific drug.

Safety: The following sub-criteria has to be considered under the criterion of safety:

* Acute therapeutic index: In the event the patient’s condition is acute, how effective is often a particular drug even when it’s certain side-effects providing the acuteness from the condition is lowered? Example: narcotic pain-killers are incredible in healing pain but include the potential side-effect of addiction.

* Long-term safety: medication could possibly be safe in short-term treatment, but how safe it is in long-term treatment? Example: antibiotics are acceptable in short-term treatment, but tend to have undesirable effects in the case of prolonged use.

* Drug-drug interaction risk: Medicine is chemicals, and lots of chemicals respond to develop a different chemical, which has an effect which could harm the person or aggravate his/her condition. Example: A tricyclic anti-depressant and alcohol interact to create a new condition that warrants separate treatment.

Drug-drug interaction risk is of two sorts:

· Pharmacokinetic: In this type of drug-drug interaction, two drugs, independent of each other, have certain effects one or even more body processes (e.g., metabolism) that affects the performance from the other. Example: Darvocet-N (propoxyphene and acetaminophen) inhibits the action of a liver enzyme that Lexapro (escitalopram) is determined by for its metabolism. This makes a boost in the side-effects of Lexapro.

· Pharmacodynamic: Here, 2 or more drugs actually make the same influence on the same organ, thus helping the total, added effect. Example: Lexapro has certain side-effects including drowsiness and fatigue. Darvocet-N also acts similarly around the brain. Thus, the side-effects of both the medicines are more intense.

Tolerability: A medicine could possibly be effective but not tolerable by all patients. Example: Allergies to specific drugs in most people. Short-term and long-term tolerability must be taken into account. Efficacy: A medicine is just not equally great at all patients. By way of example, some patients with depression or anxiety attacks experience rest from escitalopram, but there are many who don’t, who therefore must be prescribed another anti-depressant. The rate of oncoming of therapeutic action is an important the answer to be looked at too.

Cost: Cost does not always mean the expense of purchase of some medicine alone. It will also cover the expense of management of a complication which could arise while using another drug. Example: Inside a one who insists on taking alcohol yet should be treated for depression is generally administered an SSRI drug since these drugs don’t potentiate the end results of alcohol, whereas another gang of anti-depressants (including tricyclics) can cause a new problem in such patients, which will need a various and expensive treatment. Therefore, it’s safer to prescribe the more costly escitalopram instead of a cheaper tricyclic such patients.

Simple treatment: The best mode of administration is preferred. If you find an alternative between a shot and oral administration, the latter is preferred in the event the efficacy of both the modes is analogous. Or, local application is chosen over the oral route where possible; e.g., antibiotic management of eye infections. Dosage and frequency of administration too are an important factor to determine simplicity of treatment.
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SINCE World War II, medical science has progressed to a stage where competitive medications are available to treat the same ailment in several people. This is not almost brands (that is a trade issue) but generic drugs (that is a scientific issue). On this report, we shall look at the various factors that decide selecting a selected drug.

Safety: The next sub-criteria should be considered under the criterion of safety:

* Acute therapeutic index: When the patient’s condition is acute, how effective can be a particular drug regardless of whether it has certain side-effects so long as the acuteness from the condition is lowered? Example: narcotic pain-killers are very effective in healing pain but include the opportunity side-effect of addiction.

* Long-term safety: drug could be safe in short-term treatment, but wait, how safe it’s in long-term treatment? Example: antibiotics are acceptable in short-term treatment, but tend to have undesirable effects in the event of prolonged use.

* Drug-drug interaction risk: Prescription medication is chemicals, and several chemicals answer produce a different chemical, which has an effect that will harm the person or aggravate his/her condition. Example: A tricyclic anti-depressant and alcohol interact to produce a new condition that warrants separate treatment.

Drug-drug interaction risk is of two sorts:

· Pharmacokinetic: In this kind of drug-drug interaction, two drugs, independent of each other, have certain effects on a single or more body processes (e.g., metabolism) that affects the performance from the other. Example: Darvocet-N (propoxyphene and acetaminophen) inhibits the action of a liver enzyme that Lexapro (escitalopram) depends on because of its metabolism. This leads to a rise in the side-effects of Lexapro.

· Pharmacodynamic: Here, 2 or more drugs actually produce the same impact on the same organ, thus improving the total, added effect. Example: Lexapro has certain side-effects like drowsiness and fatigue. Darvocet-N also acts similarly for the brain. Thus, the side-effects of the medicine is more intense.

Tolerability: A medication could be effective and not tolerable by all patients. Example: Allergies to specific drugs in some people. Short-term and long-term tolerability must be taken into consideration. Efficacy: A medication is not equally good at all patients. As an example, some patients with depression or panic disorders experience reduced escitalopram, but there are numerous that don’t, who therefore must be prescribed an alternative anti-depressant. The pace of oncoming of therapeutic action is an important factor to be considered too.

Cost: Cost does not always mean the price of buying a particular medicine alone. It must also cover the price of treatment of a complication that will arise from utilizing an alternative drug. Example: In a person who insists on taking alcohol yet needs to be treated for depression is usually administered an SSRI drug since these drugs don’t potentiate the results of alcohol, whereas another band of anti-depressants (like tricyclics) could cause a fresh problem in such patients, which could need a various and expensive treatment. Therefore, it’s preferable to prescribe the more costly escitalopram rather than a cheaper tricyclic in this patients.

Simple treatment: The best mode of administration is preferred. If you find a selection between a shot and oral administration, the second is preferred in the event the efficacy of the modes is the identical. Or, local application is chosen over the oral route where possible; e.g., antibiotic treatment of eye infections. Dosage and frequency of administration too are a key factor to choose simplicity of treatment.
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SINCE World War II, medical science has progressed to some stage where competitive medications are available to treat exactly the same ailment in various people. It’s not nearly brands (that is a trade issue) but generic drugs (that is a scientific issue). In this report, we shall consider the various factors that decide picking a a selected drug.

Safety: These sub-criteria should be considered beneath the criterion of safety:

* Acute therapeutic index: In the event the patient’s condition is acute, how effective can be a particular drug even though it has certain side-effects so long as the acuteness in the condition is lowered? Example: narcotic pain-killers work well in healing pain but feature the possible side-effect of addiction.

* Long-term safety: drug directory could possibly be safe in short-term treatment, so how safe it can be in long-term treatment? Example: antibiotics are acceptable in short-term treatment, but can have undesirable effects in case there is prolonged use.

* Drug-drug interaction risk: Drugs are chemicals, and lots of chemicals respond to produce a different chemical, which has an effect that may harm the patient or aggravate his/her condition. Example: A tricyclic anti-depressant and alcohol interact to generate a new condition that warrants separate treatment.

Drug-drug interaction risk is of two sorts:

· Pharmacokinetic: In this type of drug-drug interaction, two drugs, outside of each other, have certain effects on a single or even more body processes (e.g., metabolism) that affects the performance in the other. Example: Darvocet-N (propoxyphene and acetaminophen) inhibits the action of a liver enzyme that Lexapro (escitalopram) is dependent upon due to the metabolism. This will cause a rise in the side-effects of Lexapro.

· Pharmacodynamic: Here, two or more drugs actually make the same relation to exactly the same organ, thus increasing the total, added effect. Example: Lexapro has certain side-effects such as drowsiness and fatigue. Darvocet-N also acts similarly for the brain. Thus, the side-effects of both prescription medication is more intense.

Tolerability: A drug could possibly be effective however, not tolerable by all patients. Example: Allergies to particular drugs in some people. Short-term and long-term tolerability have to be looked at. Efficacy: A drug is just not equally good at all patients. For instance, some patients with depression or panic disorders experience respite from escitalopram, but there are numerous that do not, who therefore have to be prescribed some other anti-depressant. The pace of onset of therapeutic action is an important factor to be regarded as too.

Cost: Cost does not necessarily mean the cost of purchase of some medicine alone. It ought to also cover the cost of treating a complication that may arise from using some other drug. Example: In a individual who insists on taking alcohol but must be treated for depression is usually administered an SSRI drug because these drugs don’t potentiate the results of alcohol, whereas another group of anti-depressants (such as tricyclics) could cause a whole new overuse injury in such patients, which will require a various and expensive treatment. Therefore, it’s safer to prescribe the more costly escitalopram rather than a cheaper tricyclic in these patients.

Simplicity of treatment: The best mode of administration is preferred. If you have a selection between an injection and oral administration, aforementioned is preferred if your efficacy of both modes is the identical. Or, local application is chosen over the oral route where possible; e.g., antibiotic treating eye infections. Dosage and frequency of administration too are an important factor to make a decision simple treatment.
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