SINCE World war 2, medical science has progressed into a stage where competitive medications are for sale to treat the same ailment in various people. It’s not almost brands (the trade issue) but generic drugs (the scientific issue). In this report, we shall look at the various factors that decide selecting a specific drug.
Safety: The next sub-criteria has to be considered under the criterion of safety:
* Acute therapeutic index: If the patient’s condition is acute, how effective is a particular drug even though it’s got certain side-effects providing the acuteness with the condition is lowered? Example: narcotic pain-killers work well in healing pain but feature the opportunity side-effect of addiction.
* Long-term safety: medicine directory could possibly be safe in short-term treatment, but wait, how safe it can be in long-term treatment? Example: antibiotics are acceptable in short-term treatment, but could have undesirable effects in the event of prolonged use.
* Drug-drug interaction risk: Prescription medication is chemicals, and lots of chemicals respond to create a different chemical, which has an effect that may harm the sufferer or aggravate his/her condition. Example: A tricyclic anti-depressant and alcohol interact to generate a new condition that warrants separate treatment.
Drug-drug interaction risk is of two types:
· Pharmacokinetic: In this kind of drug-drug interaction, two drugs, outside of the other, have certain effects using one or more body processes (e.g., metabolism) that affects the performance with the other. Example: Darvocet-N (propoxyphene and acetaminophen) inhibits the act of a liver enzyme that Lexapro (escitalopram) depends upon for its metabolism. This makes an increase in the side-effects of Lexapro.
· Pharmacodynamic: Here, several drugs actually produce the same influence on the same organ, thus improving the total, added effect. Example: Lexapro has certain side-effects such as drowsiness and fatigue. Darvocet-N also acts similarly about the brain. Thus, the side-effects of the medicine is more intense.
Tolerability: A drug could possibly be effective however, not tolerable by all patients. Example: Allergies to certain drugs in certain people. Short-term and long-term tolerability must be taken into account. Efficacy: A drug is just not equally effective in all patients. For example, some patients with depression or panic disorders experience rest from escitalopram, but there are many who don’t, who therefore must be prescribed some other anti-depressant. The speed of start of therapeutic action is a step to be considered too.
Cost: Cost does not always mean the price of buying some medicine alone. It should also cover the price of treating a complication that may arise from using some other drug. Example: Inside a person who insists on taking alcohol yet needs to be treated for depression is often administered an SSRI drug as these drugs don’t potentiate the end results of alcohol, whereas another band of anti-depressants (such as tricyclics) could cause a brand new symptom in such patients, which will require a various and expensive treatment. Therefore, it’s better to prescribe the more costly escitalopram rather than a cheaper tricyclic in these patients.
Simplicity of treatment: The simplest mode of administration is preferred. If there is a choice between an injection and oral administration, rogues is preferred when the efficacy of the modes is comparable. Or, local application is preferred to the oral route where possible; e.g., antibiotic treating eye infections. Dosage and frequency of administration too are key point to make a decision simplicity of treatment.
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